Compound ID | 103

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Benzimidazole-Based FABI inhibitor 1

Class: Fatty acid synthesis inhibitor (FabI inhibitor)

Spectrum of activity: Gram-positive
Details of activity: Inhibits FabI, which determines the completing of each cycle of elongation in the fatty acid synthesis. Designed for Francisella tularensis.
Institute where first reported: University of Illinois at Chicago, USA
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight: 305.2
Iso. SMILES: CC1=CC2=C(C=C1C)N(C=N2)CC3=CC(=C(C=C3)Cl)Cl
InChI Key: PCJBTWVYIQBUCM-UHFFFAOYSA-N
Can. SMILES: CC1=CC2=C(C=C1C)N(CC3=CC=C(C(=C3)Cl)Cl)C=N2
InChI: InChI=1S/C16H14Cl2N2/c1-10-5-15-16(6-11(10)2)20(9-19-15)8-12-3-4-13(17)14(18)7-12/h3-7,9H,8H2,1-2H3
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/2949939
Citations:
  • http://pubs.acs.org/doi/abs/10.1021/acsinfecdis.6b00123
  • https://www.sciencedirect.com/science/article/pii/S0960894X15000608?casa_token=VjSLxsY8VmQAAAAA:XMy3jLRPqJHWbnzP7DAK0IZsrrVdmFF5lRxEfCXnXHrUSXEoXb5Eo-THt9jy8dDdrCr8CyKjUAw
  • http://www.ncbi.nlm.nih.gov/pubmed/22642319
  • https://pubs.acs.org/doi/10.1021/jm300489v

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