Compound ID | 1038

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Madumycin II

Synonym(s): A2315A

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Inhibits the formation of first peptide bond during translation; stalls the ribosome at the start codon with the initiator fMet-tRNAfMet bound to the P site
Institute where first reported: Elli Lilly and Company.
Year first mentioned: 1974
Development status: Experimental
Chemical structure(s):
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Molecular weight: 503.59
Iso. SMILES: C[C@@H]1/C=C/C(=O)NC/C=C/C(=C/[C@H](C[C@@H](CC2=NC(=CO2)C(=O)N[C@@H](C(=O)O[C@@H]1C(C)C)C)O)O)/C
InChI Key: SAQNYTQFLPVTNJ-WWUMGCNISA-N
Can. SMILES: CC(C)[C@@H]1[C@H](C)/C=C/C(=O)NC/C=C/C(=C/[C@H](C[C@@H](CC2=NC(=CO2)C(=O)N[C@H](C)C(=O)O1)O)O)/C
InChI: InChI=1S/C26H37N3O7/c1-15(2)24-17(4)8-9-22(32)27-10-6-7-16(3)11-19(30)12-20(31)13-23-29-21(14-35-23)25(33)28-18(5)26(34)36-24/h6-9,11,14-15,17-20,24,30-31H,10,12-13H2,1-5H3,(H,27,32)(H,28,33)/b7-6+,9-8+,16-11+/t17-,18-,19-,20+,24-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/21596528
Guide to Pharmacology: A2315A

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