Compound ID | 1047
Fludalanine
Synonym(s): 2-2H-3-fluoro-D-alanine | Fluoroalanine
Class: Cell wall synthesis inhibitor
| Agent Type: | Synthetic; Small molecule; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Cell wall synthesis inhibitor. D-Alanine racemase inhibitor |
| Combined with other compounds: | Yes |
| Description: | 1. Kahan, F. M., and H. Kropp. "MK641/MK642. A fixed-ratio combination antimicrobial. 1 Rationale: The sequential blockade of bacterial cell-wall biosynthesis." Program and Abstracts of the 15th Intersci. Conf. on Antimicrob. Agents Chemother. No. 100. 1975. 2. Wise, R., and J. M. Andrews. "In vitro activity of fludalanine combined with pentizidone compared with those of other agents." Antimicrobial agents and chemotherapy 25.5 (1984): 612-617. |
| Institute where first reported: | Merk Sharpe and Dohme Laboratories. |
| Year first mentioned: | 1975 |
| Highest development stage: | Preclinical |
| Development status: | Experimental |
| Reason dropped: | High levels of patient toxicity |
| Chemical structure(s): | |||||||||||
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| External links: | |
| PubChem link: | https://pubchem.ncbi.nlm.nih.gov/compound/146933 |
| Guide to Pharmacology: | fludalanine |
| Citation: | https://pubmed.ncbi.nlm.nih.gov/2877824/ |
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