Fludalanine/pentizadone

Class: D-alanine racemase inhibitor

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Cell wall component mimetics.
Combined with other compounds:	Yes
Description:	1. Kahan, F. M., and H. Kropp. "MK641/MK642. A fixed-ratio combination antimicrobial. 1 Rationale: The sequential blockade of bacterial cell-wall biosynthesis." Program and Abstracts of the 15th Intersci. Conf. on Antimicrob. Agents Chemother. No. 100. 1975. 2. Wise, R., and J. M. Andrews. "In vitro activity of fludalanine combined with pentizidone compared with those of other agents." Antimicrobial agents and chemotherapy 25.5 (1984): 612-617.
Institute where first reported:	Merk Sharpe and Dohme Laboratories.
Year first mentioned:	1975
Highest developmental phase:	Preclinical
Reason Dropped:	High levels of patient toxicity.

Chemical structure(s):
Canonical SMILES:	C([C@]([2H])(C(=O)O)N)F
Isomeric SMILES:	[2H][C@@](CF)(C(=O)O)N
InChI:	InChI=1S/C3H6FNO2/c4-1-2(5)3(6)7/h2H,1,5H2,(H,6,7)/t2-/m1/s1/i2D
InChI Key:	UYTSRQMXRROFPU-LIIDHCAMSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/146933

External links:
Guide to Pharmacology:	fludalanine