Apalcillin (PC-904)

Class: Beta-lactam (penicillin)

Spectrum of activity:	Gram-negative
Propensity to select resistant mutants:	Yes
Description:	Beta lactam, highly active against Pseudomonas. Dropped because of toxicity problems.
Institute where first reported:	Sumito Chemical
Year first mentioned:	1975
Highest developmental phase:	Preclinical

Chemical structure(s):
Canonical SMILES:	CC1(C)[C@H](C(=O)O)N2C(=O)[C@H]([C@H]2S1)NC(=O)[C@@H](C3=CC=CC=C3)NC(=O)C4=CNC5=CC=CN=C5C4=O
Isomeric SMILES:	CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)NC(=O)C4=CNC5=C(C4=O)N=CC=C5)C(=O)O)C
InChI:	InChI=1S/C25H23N5O6S/c1-25(2)19(24(35)36)30-22(34)17(23(30)37-25)29-21(33)15(12-7-4-3-5-8-12)28-20(32)13-11-27-14-9-6-10-26-16(14)18(13)31/h3-11,15,17,19,23H,1-2H3,(H,27,31)(H,28,32)(H,29,33)(H,35,36)/t15-,17-,19+,23-/m1/s1
InChI Key:	XMQVYNAURODYCQ-SLFBBCNNSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6602341

External links:
Guide to Pharmacology:	apalcillin
Citation:	https://www.ncbi.nlm.nih.gov/pubmed/1046355