Compound ID | 1062

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Sulbactam + Carbenicillin

Class: Drug combination: beta-lactam (Penicillin) + beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Shows activity against ampicillin hemophilus influenza
Year first mentioned: 1978
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Inconsistancy of synergy.
Chemical structure(s):
Sulbactam
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Molecular weight: 233.24
Iso. SMILES: CC1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)C
InChI Key: FKENQMMABCRJMK-RITPCOANSA-N
Can. SMILES: CC1(C)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
InChI: InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
Carbenicillin
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Molecular weight: 378.4
Iso. SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(C3=CC=CC=C3)C(=O)O)C(=O)O)C
InChI Key: FPPNZSSZRUTDAP-UWFZAAFLSA-N
Can. SMILES: CC1(C)[C@H](C(=O)O)N2C(=O)[C@H]([C@H]2S1)NC(=O)C(C3=CC=CC=C3)C(=O)O
InChI: InChI=1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25)/t9?,10-,11+,14-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/130313
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/20824
Guide to Pharmacology: sulbactam
Citations:
  • http://aac.asm.org/content/19/2/361

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