Compound ID | 1084

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Lysinomicin

Class: Aminoglycoside

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Unknown
Target Pathogen: Broad spectrum activity including towards gentamicin-resistant strains
Description: JACKSON, M., et al. "Lysinomicin, a new aminoglycoside antibiotic. I. Taxonomy of the producing organism, fermentation, isolation and biological properties. Session 21, Abstract 183. 21st Intersci." Conf. Antimicrob. Agents & Chemother., Chicago. 1981.
Institute where first reported: Abbott Laboratories
Year first mentioned: 1981
Development status: Experimental
Chemical structure(s):
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Molecular weight: 460.57
Iso. SMILES: CN[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1OC)O)N)O[C@@H]2[C@@H](CC=C(O2)CN)NC(=O)C[C@H](CCCN)N)O
InChI Key: WTENXKAJCSHCNH-QJSCRMMJSA-N
Can. SMILES: CN[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1OC)O)N)O[C@@H]2[C@@H](CC=C(CN)O2)NC(=O)C[C@H](CCCN)N)O
InChI: InChI=1S/C20H40N6O6/c1-25-15-17(29)18(14(24)16(28)19(15)30-2)32-20-12(6-5-11(9-22)31-20)26-13(27)8-10(23)4-3-7-21/h5,10,12,14-20,25,28-29H,3-4,6-9,21-24H2,1-2H3,(H,26,27)/t10-,12+,14-,15-,16-,17+,18+,19-,20+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/196541
Guide to Pharmacology: lysinomicin
Citation: https://doi.org/10.7164/antibiotics.37.1130

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