Compound ID | 1087

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SK&F 88070

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Stable to beta-lactamase activity
Description: High prolonged levels in blood
Institute where first reported: Smith Kline and French Laboratories
Year first mentioned: 1981
Development status: Experimental
Chemical structure(s):
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Molecular weight: 620.67
Iso. SMILES: CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CSC4=NN=NN4CCNS(=O)(=O)O)C(=O)O
InChI Key: ARWJIPOQKKRGCN-UPRLUYEASA-N
Can. SMILES: CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@@H]2C(=O)N3C(=C(CS[C@H]23)CSC4=NN=NN4CCNS(=O)(=O)O)C(=O)O
InChI: InChI=1S/C17H20N10O8S4/c1-35-23-9(8-6-37-16(18)20-8)12(28)21-10-13(29)27-11(15(30)31)7(4-36-14(10)27)5-38-17-22-24-25-26(17)3-2-19-39(32,33)34/h6,10,14,19H,2-5H2,1H3,(H2,18,20)(H,21,28)(H,30,31)(H,32,33,34)/b23-9-/t10-,14-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9571087
Guide to Pharmacology: SK&F 88070
Citations:
  • http://aac.asm.org/content/25/6/694
  • https://doi.org/10.1128/aac.28.2.343

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