Compound ID | 1091

Update compound information

Maduramicin

Synonym(s): X-14868A  |  Cygro

Class: Polyether antibiotic

Spectrum of activity: Gram-negative
Details of activity: Active against gram + bacteria and also active in controlling coccidiosis in chickens
Description: WESTLEY, J. W.; C.-M. LIU, J. F. BLOUNT, R. H. EVANS, L. H. SELLO, N. TROUPE & P. A. MILLER: Novel polyether antibiotics X-14868A, B, C and D: Potent coccidiostats from Nocardia. In Trends in Antibiotic Research. Genetics, Biosyntheses, Actions & New Substances. Ed., H. UMEZAWA et al., pp. 125-134, Japan Antibiotics Res. Assoc., Tokyo, 1982
Institute where first reported: Hoffman-La Roche Inc
Year first mentioned: 1982
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 917.13
Iso. SMILES: C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@H](O2)[C@@]3(CC[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@H]6[C@@H]([C@H]([C@@H]([C@](O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)O[C@@H]7C[C@@H]([C@H]([C@@H](O7)C)OC)OC)(C)O)C
InChI Key: RWVUEZAROXKXRT-VQLSFVLHSA-N
Can. SMILES: C[C@H]1C[C@@H](C)[C@@](C)(O)O[C@@H]1[C@H]2C[C@@H]([C@H]([C@]3(C)CC[C@H]([C@]4(C)CC[C@]5(C[C@@H]([C@@H](C)[C@@H]([C@@H](C)[C@H]6[C@@H]([C@H]([C@H](C)[C@](CC(=O)O)(O)O6)OC)OC)O5)O)O4)O3)O2)O[C@@H]7C[C@@H]([C@H]([C@H](C)O7)OC)OC
InChI: InChI=1S/C47H80O17/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50)/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/196129
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/39/12/39_12_1704/_pdf
  • https://www.jstage.jst.go.jp/article/antibiotics1968/36/4/36_4_343/_article

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