Compound ID | 1093

Update compound information

X-14868C

Class: Polyether antibiotic

Spectrum of activity: Gram-negative
Details of activity: Active against gram + bacteria and also active in controlling coccidiosis in chickens
Description: WESTLEY, J. W.; C.-M. LIU, J. F. BLOUNT, R. H. EVANS, L. H. SELLO, N. TROUPE & P. A. MILLER: Novel polyether antibiotics X-14868A, B, C and D: Potent coccidiostats from Nocardia. In Trends in Antibiotic Research. Genetics, Biosyntheses, Actions & New Substances. Ed., H. UMEZAWA et al., pp. 125-134, Japan Antibiotics Res. Assoc., Tokyo, 1982
Institute where first reported: Hoffman-La Roche Inc
Year first mentioned: 1982
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 903.1
Iso. SMILES: C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@H](O2)[C@@]3(CC[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@H]6[C@@H]([C@H]([C@@H]([C@](O6)(CC(=O)O)O)C)O)OC)C)O)C)C)O[C@@H]7C[C@@H]([C@H]([C@@H](O7)C)OC)OC)(C)O)C
InChI Key: YLJZFEIUUCJGFL-SPDLRFCQSA-N
Can. SMILES: C[C@H]1C[C@@H](C)[C@@](C)(O)O[C@@H]1[C@H]2C[C@@H]([C@H]([C@]3(C)CC[C@H]([C@]4(C)CC[C@]5(C[C@@H]([C@@H](C)[C@@H]([C@@H](C)[C@H]6[C@@H]([C@H]([C@H](C)[C@](CC(=O)O)(O)O6)O)OC)O5)O)O4)O3)O2)O[C@@H]7C[C@@H]([C@H]([C@H](C)O7)OC)OC
InChI: InChI=1S/C46H78O17/c1-22-17-23(2)44(9,51)60-36(22)30-18-31(57-34-19-29(53-10)39(54-11)27(6)56-34)41(58-30)43(8)14-13-32(59-43)42(7)15-16-45(63-42)20-28(47)24(3)37(61-45)25(4)38-40(55-12)35(50)26(5)46(52,62-38)21-33(48)49/h22-32,34-41,47,50-52H,13-21H2,1-12H3,(H,48,49)/t22-,23+,24+,25+,26-,27-,28-,29-,30+,31-,32+,34+,35-,36-,37-,38-,39-,40+,41+,42-,43-,44-,45+,46+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/101282738
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/39/12/39_12_1704/_pdf

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