Cationomycin

Class: Polyether antibiotic

Spectrum of activity:	Gram-positive
Details of activity:	Active against gram + bacteria but showed 'remarkable' anti coccidiostat activity in sheep.
Institute where first reported:	The institute of physical and chemical research, Wako-shi, Japan.
Year first mentioned:	1982
Highest developmental phase:	Preclinical
Development status:	Inactive
Reason Dropped:	Limitted efficacy against bacteria

Chemical structure(s):
Canonical SMILES:	CC[C@H]([C@]1(C)C[C@H](C)[C@@H]([C@H]2C[C@H](C)[C@H]([C@]3(C)[C@H](C[C@H]([C@]4(C)CC[C@]5(C[C@@H]([C@@H](C)[C@@H]([C@@H](C)[C@H]([C@](C)(C(=O)O)O)OC(=O)C6=C(C)C=C(C=C6O)OC)O5)O)O4)O3)OC)O2)O1)O
Isomeric SMILES:	CC[C@H]([C@@]1(C[C@@H]([C@H](O1)[C@H]2C[C@@H]([C@@H](O2)[C@@]3([C@H](C[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@H]([C@](C)(C(=O)O)O)OC(=O)C6=C(C=C(C=C6C)OC)O)C)O)C)OC)C)C)C)C)O
InChI:	InChI=1S/C45H70O15/c1-13-31(48)42(8)20-24(4)35(58-42)30-17-23(3)37(55-30)44(10)33(54-12)19-32(57-44)41(7)14-15-45(60-41)21-29(47)25(5)36(59-45)26(6)38(43(9,52)40(50)51)56-39(49)34-22(2)16-27(53-11)18-28(34)46/h16,18,23-26,29-33,35-38,46-48,52H,13-15,17,19-21H2,1-12H3,(H,50,51)/t23-,24-,25+,26+,29-,30+,31+,32+,33-,35-,36-,37+,38+,41-,42-,43+,44-,45+/m0/s1
InChI Key:	TZXAYLJEVNVSIA-XFOYJMOZSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/10485723

External links:
Guide to Pharmacology:	cationomycin
Citation:	https://www.jstage.jst.go.jp/article/antibiotics1968/34/11/34_11_1513/_article