Compound ID | 1106

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Sarafloxacin

Synonym(s): A-56620

Class: Quinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Propensity to select resistant mutants: Yes
Description: D.T.W, Chu et al."A-56619 and A56620: Synthesis and antibacterial activity of the novel aryl-fluoroquinolones and their analogs [Abstract 72]" Programs and abstracts of the 24St Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington.DC. American Society for Microbiology. 1984.
Institute where first reported: Abbott Laboratories
Year first mentioned: 1984
Highest developmental phase: Phase 4
Development status: Inactive
Reason Dropped: Withdrawn from the market in 2001due to high incidence of phototoxicity
Chemical structure(s):
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Molecular weight: 385.36
Iso. SMILES: C1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F
InChI Key: XBHBWNFJWIASRO-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)N2C=C(C(=O)C3=C2C=C(C(=C3)F)N4CCNCC4)C(=O)O)F
InChI: InChI=1S/C20H17F2N3O3/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24/h1-4,9-11,23H,5-8H2,(H,27,28)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/56208
Guide to Pharmacology: sarafloxacin
Citation:

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