Sarafloxacin

Synonym(s): A-56620

Class: Quinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Propensity to select resistant mutants:	Yes
Description:	D.T.W, Chu et al."A-56619 and A56620: Synthesis and antibacterial activity of the novel aryl-fluoroquinolones and their analogs [Abstract 72]" Programs and abstracts of the 24St Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington.DC. American Society for Microbiology. 1984.
Institute where first reported:	Abbott Laboratories
Year first mentioned:	1984
Highest developmental phase:	Phase 4
Development status:	Inactive
Reason Dropped:	Withdrawn from the market in 2001due to high incidence of phototoxicity

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)N2C=C(C(=O)C3=C2C=C(C(=C3)F)N4CCNCC4)C(=O)O)F
Isomeric SMILES:	C1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F
InChI:	InChI=1S/C20H17F2N3O3/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24/h1-4,9-11,23H,5-8H2,(H,27,28)
InChI Key:	XBHBWNFJWIASRO-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/56208

External links:
Guide to Pharmacology:	sarafloxacin