Compound ID | 1111

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LY171217

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-positive  &  Gram-negative
Description: D.A. Preston et al.Preclinical Bacteriological evaluation of LY164846, A New Orally Absorbed Cephalosporin Antibiotic [Abstract 229]" Programs and abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington.DC. American Society for Microbiology. 1984.
Institute where first reported: The Lilly Research Laboratories
Year first mentioned: 1984
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: High levels of Nephrotoxicity shown in mice
Chemical structure(s):
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Molecular weight: 397.45
Iso. SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC4=CC=CC=C4C=C3)N)SC1)C(=O)O
InChI Key: VQEWIGYVZJQQKA-SPYBWZPUSA-N
Can. SMILES: CC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)NC(=O)[C@@H](C3=CC4=C(C=CC=C4)C=C3)N
InChI: InChI=1S/C20H19N3O4S/c1-10-9-28-19-15(18(25)23(19)16(10)20(26)27)22-17(24)14(21)13-7-6-11-4-2-3-5-12(11)8-13/h2-8,14-15,19H,9,21H2,1H3,(H,22,24)(H,26,27)/t14-,15-,19-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/13339667
Citation:

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