Compound ID | 1122

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Tigemonam

Synonym(s): SQ 30213

Class: Beta-lactam (monobactam)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Good activty against gram negative bacteria with the exception of Pseudomonas.
Description: Chin, N. X., and H. C. Neu. "Tigemonam, an oral monobactam." Antimicrobial agents and chemotherapy 32.1 (1988): 84-91.
Institute where first reported: Bristol Myers Squibb
Year first mentioned: 1985
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Discontinued in 1994 due to…
Chemical structure(s):
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Molecular weight: 437.41
Iso. SMILES: CC1([C@@H](C(=O)N1OS(=O)(=O)O)NC(=O)/C(=N\OCC(=O)O)/C2=CSC(=N2)N)C
InChI Key: VAMSVIZLXJOLHZ-QWFSEIHXSA-N
Can. SMILES: CC1(C)[C@@H](C(=O)N1OS(=O)(=O)O)NC(=O)/C(=N\OCC(=O)O)/C2=CSC(=N2)N
InChI: InChI=1S/C12H15N5O9S2/c1-12(2)8(10(21)17(12)26-28(22,23)24)15-9(20)7(16-25-3-6(18)19)5-4-27-11(13)14-5/h4,8H,3H2,1-2H3,(H2,13,14)(H,15,20)(H,18,19)(H,22,23,24)/b16-7-/t8-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9576769
Guide to Pharmacology: tigemonam
Citation:
Patent: US20140128364A1

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