Compound ID | 1125

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LY164846

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad spectrum
Propensity to select resistant mutants: Yes
Description: Jones, R. N., et al. "LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks." Antimicrobial agents and chemotherapy 29.3 (1986): 530-534.
Institute where first reported: Columbia University
Year first mentioned: 1985
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Susceptibility to Cephalosporinases
Chemical structure(s):
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Molecular weight: 403.48
Iso. SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CSC4=CC=CC=C43)N)SC1)C(=O)O
InChI Key: UZIXWKQHCIOPLV-PBFPGSCMSA-N
Can. SMILES: CC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)NC(=O)[C@@H](C3=CSC4=C3C=CC=C4)N
InChI: InChI=1S/C18H17N3O4S2/c1-8-6-27-17-13(16(23)21(17)14(8)18(24)25)20-15(22)12(19)10-7-26-11-5-3-2-4-9(10)11/h2-5,7,12-13,17H,6,19H2,1H3,(H,20,22)(H,24,25)/t12-,13-,17-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/14021703
Citation: https://www.sciencedirect.com/science/article/pii/073288938790112X?via%3Dihub

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