Compound ID | 1128

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E-4695

Synonym(s): E4695  |  E 4695

Class: Quinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Improved activity against gram positive pathogens when compared to ciprofloxacin, and also matches its activity against gram negatives. 7-Azetidinyl Quinolone; in vitro activty is more potent or equal to ciprofloxacin against: S. aureus, E. faecalis, Pneumococcus, E. coli, P. stuartii, Acinetobacters, P aeruginosa and H. influenzae
Description: Xicota, M.A., et al. "Antibacterial In Vitro Profile of E-4695, a Potent 7-Azetidyl Quinolone" Program and Abstracts of the 31st Intersci. Conf. on Antimicrob. Agents Chemother. No. 374.
Institute where first reported: Esteve, Spain
Year first mentioned: 1991
Highest developmental phase: Preclinical
Development status: Experimental
Chemical structure(s):
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Molecular weight: 332.33
Iso. SMILES: C[C@H]1[C@@H](CN1C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F)N
InChI Key: AUJKWLGOXRSXRX-JVXZTZIISA-N
Can. SMILES: C[C@H]1[C@@H](CN1C2=NC3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)N
InChI: InChI=1S/C16H17FN4O3/c1-7-12(18)6-20(7)15-11(17)4-9-13(22)10(16(23)24)5-21(8-2-3-8)14(9)19-15/h4-5,7-8,12H,2-3,6,18H2,1H3,(H,23,24)/t7-,12+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/125566
Citation: https://journals.asm.org/doi/10.1128/aac.39.2.413

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