Compound ID | 113

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PT52 (Diphenyl ether)

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Fatty acid synthesis inhibitor. FabI inhibitor
Target Pathogen: Designed for Burkholderia pseudomallei melioidosis
Institute where first reported: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 220.65
Iso. SMILES: C1=CC=C(C=C1)OC2=C(C=C(C=C2)Cl)O
InChI Key: ZVTLRRZWZYDDLD-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2O)Cl
InChI: InChI=1S/C12H9ClO2/c13-9-6-7-12(11(14)8-9)15-10-4-2-1-3-5-10/h1-8,14H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5271320
Citations:
  • http://aac.asm.org/content/58/3/1646.full
  • https://journals.asm.org/doi/full/10.1128/aac.02296-13
    • Patent: US10071965B2

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