Sanfetrinem cilexetil

Synonym(s): GV118819

Class: Beta-lactam

Spectrum of activity:	Gram-positive
Details of activity:	Orally available prodrug ester of GV104326, improved activity against gram positive pathogens.
Description:	Hammond.S,M., et al. "GV118819 an orally absorbed prodrug ester of the tribactam GV104326"" Program and Abstracts of the 32st Intersci. Conf. on Antimicrob. Agents Chemother. No. 130.
Institute where first reported:	GlaxoSmithKline
Year first mentioned:	1992
Highest developmental phase:	Phase 2
Development status:	Inactive
Reason Dropped:	Discontinued in 1999

Chemical structure(s):
Canonical SMILES:	C[C@H]([C@@H]1[C@H]2[C@H]3CCC[C@@H](C3=C(C(=O)OC(C)OC(=O)OC4CCCCC4)N2C1=O)OC)O
Isomeric SMILES:	C[C@H]([C@@H]1[C@H]2[C@H]3CCC[C@@H](C3=C(N2C1=O)C(=O)OC(C)OC(=O)OC4CCCCC4)OC)O
InChI:	InChI=1S/C23H33NO8/c1-12(25)17-19-15-10-7-11-16(29-3)18(15)20(24(19)21(17)26)22(27)30-13(2)31-23(28)32-14-8-5-4-6-9-14/h12-17,19,25H,4-11H2,1-3H3/t12-,13?,15+,16+,17-,19-/m1/s1
InChI Key:	QFEICXCLIGZEJB-IRVPUMQPSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6918217

External links:
Guide to Pharmacology:	sanfetrinem