Compound ID | 1132

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E 1101

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-positive
Description: Negi.S., et al. "E1101, a New Oral Cephalosporin: 1. Synthesis abd Structure-Activity Relations of 3-Substituted Carbamoyloxymethyl Cephems" Program and Abstracts of the 33st Intersci. Conf. on Antimicrob. Agents Chemother. No. 894.
Institute where first reported: Eisai Co
Year first mentioned: 1993
Highest development stage: Preclinical
Development status: Inactive
Reason dropped: Less effective than competitors
Chemical structure(s):
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Molecular weight: 637.09
Iso. SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(CS[C@H]2N1C(=O)C2NC(=O)/C(=N/O)/C3=CSC(=N3)N)COC(=O)N(C)C.Cl
InChI Key: OKKNLGCBBUIKCA-KTTSAYCYSA-N
Can. SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(COC(=O)N(C)C)CS[C@@H]2C(C(=O)N12)NC(=O)/C(=N/O)/C3=CSC(=N3)N.Cl
InChI: InChI=1S/C22H28N6O10S2.ClH/c1-9(2)36-22(33)38-10(3)37-19(31)15-11(6-35-21(32)27(4)5)7-39-18-14(17(30)28(15)18)25-16(29)13(26-34)12-8-40-20(23)24-12;/h8-10,14,18,34H,6-7H2,1-5H3,(H2,23,24)(H,25,29);1H/b26-13+;/t10?,14?,18-;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9578014

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