Compound ID | 1134

Update compound information

BMS-180680

Synonym(s): PA 1806

Class: Beta-lactam (monobactam)

Details of activity: Broad spectrum antibiotic that is able to protect mice from Pseudomonal lung infection better than cefeprime and ceftazidime; cell wall inhibitor
Description: Catechol-containing monobactam Kolek.B., et al. "In Vitro Activity of a Novel Catechol-Containing Monobactam, BMS-180680." Program and Abstracts of the 34th Intersci. Conf. on Antimicrob. Agents Chemother. No.F143.
Institute where first reported: Bristol-Myers Squibb, UK
Year first mentioned: 1994
Highest developmental phase: Phase 2
Development status: Inactive
Reason Dropped: Discontinued for respiratory tract infections in the US in 2002
Chemical structure(s):
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Molecular weight: 567.51
Iso. SMILES: C[C@@H]1[C@@H](C(=O)N1S(=O)(=O)O)NC(=O)/C(=N\OCC2=NC3=CC(=C(C=C3N=C2C(=O)O)O)O)/C4=CSC(=N4)N
InChI Key: FAUHVXXXXAHABE-VHLYPECSSA-N
Can. SMILES: C[C@@H]1[C@@H](C(=O)N1S(=O)(=O)O)NC(=O)/C(=N\OCC2=C(C(=O)O)N=C3C=C(C(=CC3=N2)O)O)/C4=CSC(=N4)N
InChI: InChI=1S/C19H17N7O10S2/c1-6-13(17(30)26(6)38(33,34)35)24-16(29)14(10-5-37-19(20)23-10)25-36-4-9-15(18(31)32)22-8-3-12(28)11(27)2-7(8)21-9/h2-3,5-6,13,27-28H,4H2,1H3,(H2,20,23)(H,24,29)(H,31,32)(H,33,34,35)/b25-14-/t6-,13+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135462917
Citation:

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