Compound ID | 114

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PT68 (Diphenyl ether)

Class: Fatty acid synthesis inhibitor (FabI inhibitor)

Spectrum of activity: Gram-negative
Details of activity: Inhibits FabI, which determines the completing of each cycle of elongation in the fatty acid synthesis. Designed for B. pseudomallei melioidosis
Institute where first reported: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
Year first mentioned: 2013
Development status: Experimental
Chemical structure(s):
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Molecular weight: 226.27
Iso. SMILES: C=CCC1=CC(=C(C=C1)OC2=CC=CC=C2)O
InChI Key: DBZGFSBCPYRHRA-UHFFFAOYSA-N
Can. SMILES: C=CCC1=CC=C(C(=C1)O)OC2=CC=CC=C2
InChI: InChI=1S/C15H14O2/c1-2-6-12-9-10-15(14(16)11-12)17-13-7-4-3-5-8-13/h2-5,7-11,16H,1,6H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71464708
Citations:
  • http://aac.asm.org/content/58/3/1646.full
  • https://journals.asm.org/doi/full/10.1128/aac.02296-13
    • Patent: US10071965B2

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