Compound ID | 1148

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SKF 12141 (2-biphenyl penicillin)

Synonym(s): Anicillin (sodium monohydrate salt)

Class: Beta-lactam (penicillin)

Spectrum of activity: Gram-positive
Details of activity: Activty against Staphylococci and Streptococcus pyogenes
Description: Dolan, M. M et al. "A new synthetic penicillin, SK&F 12141" Program and Abstracts of the interscience science Conference on Antimicrobial Agents and Chemotherapy. 1961.
Institute where first reported: Smith Kline and French Laboratories
Year first mentioned: 1961
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Poor half life in serum
Chemical structure(s):
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Molecular weight: 396.46
Iso. SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C3=CC=CC=C3C4=CC=CC=C4)C(=O)O)C
InChI Key: BBQSZMJQBZBHAO-JTDSTZFVSA-N
Can. SMILES: CC1(C)[C@H](C(=O)O)N2C(=O)[C@H]([C@H]2S1)NC(=O)C3=C(C=CC=C3)C4=CC=CC=C4
InChI: InChI=1S/C21H20N2O4S/c1-21(2)16(20(26)27)23-18(25)15(19(23)28-21)22-17(24)14-11-7-6-10-13(14)12-8-4-3-5-9-12/h3-11,15-16,19H,1-2H3,(H,22,24)(H,26,27)/t15-,16+,19-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/120650
Citations:
  • https://experts.umn.edu/en/publications/treatment-of-severe-staphylococcal-infections-with-ancillin
  • https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/568668

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