Compound ID | 115

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VT-02-00068

Class: Fatty acid synthesis inhibitor (FabI inhibitor)

Spectrum of activity: Gram-positive
Details of activity: Inhibits FabI, which determines the completing of each cycle of elongation in the fatty acid synthesis.
Description: Derivative of AFN-1252
Institute where first reported: Vitas Pharma, India
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 389.45
Iso. SMILES: CC1=C(OC2=CC=CC=C12)CN(C)C(=O)/C=C/C3=CC4=C(NC(=O)C4(C)C)N=C3
InChI Key: RVBSHRUYJYRNJW-MDZDMXLPSA-N
Can. SMILES: CC1=C(CN(C)C(=O)/C=C/C2=CN=C3C(=C2)C(C)(C)C(=O)N3)OC4=C1C=CC=C4
InChI: InChI=1S/C23H23N3O3/c1-14-16-7-5-6-8-18(16)29-19(14)13-26(4)20(27)10-9-15-11-17-21(24-12-15)25-22(28)23(17,2)3/h5-12H,13H2,1-4H3,(H,24,25,28)/b10-9+
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/71506854
Citations:
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=VITAS+&id=2173&L=0&x=0&y=0
  • https://patents.google.com/patent/US20140249170A1/en
    • Patent: US20140249170A1

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