Compound ID | 1153

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Stravidin

Synonym(s): MSD-235

Class: Antimicrobial peptide (biotin antimetabolie)

Spectrum of activity: Gram-negative
Details of activity: Binds to biotin, causes biotin deficiency and growth inhibition; synergistic activity in complex with stravidins; active against Enterobacterales
Description: Chaiet, L. "Antibiotic MSD-235. Production by streptomyces avidinii" Program and Abstracts of the interscience science Conference on Antimicrobial Agents and Chemotherapy. 1963.
Institute where first reported: Merck Sharp
Year first mentioned: 1963
Highest developmental phase: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 323.43
Iso. SMILES: CCC(C)C(C(=O)NC(CCC1C=CC(C=C1)N)C(=O)O)NC
InChI Key: ATAHFPOIIFBWFN-UHFFFAOYSA-N
Can. SMILES: CCC(C)C(C(=O)NC(CCC1C=CC(C=C1)N)C(=O)O)NC
InChI: InChI=1S/C17H29N3O3/c1-4-11(2)15(19-3)16(21)20-14(17(22)23)10-7-12-5-8-13(18)9-6-12/h5-6,8-9,11-15,19H,4,7,10,18H2,1-3H3,(H,20,21)(H,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/Stravidin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/14274921/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230017/
  • https://www.semanticscholar.org/paper/The-constitution-of-stravidin%2C-a-novel-product-Baggaley-Blessington/d30d6c1b2709ba85366515d3ce7bc9d8be89b335

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