Compound ID | 116

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FAB001

Synonym(s): MUT056399

Class: Fatty acid synthesis inhibitor (FabI inhibitor)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Inhibits FabI, which determines the completing of each cycle of elongation in the fatty acid synthesis.
Propensity to select resistant mutants: Yes
Institute where first reported: Fab Pharmaceuticals, India, Mutabilis
Year first mentioned: 2009
Highest developmental phase: Phase 1
Development status: Inactive
Chemical structure(s):
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Molecular weight: 293.27
Iso. SMILES: CCC1=CC(=C(C=C1F)OC2=C(C=C(C=C2)C(=O)N)F)O
InChI Key: QUHARGDBJJUOEB-UHFFFAOYSA-N
Can. SMILES: CCC1=C(C=C(C(=C1)O)OC2=CC=C(C=C2F)C(=O)N)F
InChI: InChI=1S/C15H13F2NO3/c1-2-8-6-12(19)14(7-10(8)16)21-13-4-3-9(15(18)20)5-11(13)17/h3-7,19H,2H2,1H3,(H2,18,20)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/44208849
Guide to Pharmacology: MUT056399
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/24002361
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186954/

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