FAB001

Synonym(s): MUT056399

Class: Fatty acid synthesis inhibitor (FabI inhibitor)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits FabI, which determines the completing of each cycle of elongation in the fatty acid synthesis.
Propensity to select resistant mutants:	Yes
Institute where first reported:	Fab Pharmaceuticals, India, Mutabilis
Year first mentioned:	2009
Highest developmental phase:	Phase 1
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CCC1=C(C=C(C(=C1)O)OC2=CC=C(C=C2F)C(=O)N)F
Isomeric SMILES:	CCC1=CC(=C(C=C1F)OC2=C(C=C(C=C2)C(=O)N)F)O
InChI:	InChI=1S/C15H13F2NO3/c1-2-8-6-12(19)14(7-10(8)16)21-13-4-3-9(15(18)20)5-11(13)17/h3-7,19H,2H2,1H3,(H2,18,20)
InChI Key:	QUHARGDBJJUOEB-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/44208849

External links:
Guide to Pharmacology:	MUT056399
Citations:	https://www.ncbi.nlm.nih.gov/pubmed/24002361 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186954/