Maridomycin

Synonym(s): LS-87912, mono, di, and tri acyl derivatives

Class: Macrolide

Spectrum of activity:	Gram-positive
Details of activity:	Active against Gram-positive bacteria, identical to Josamycin
Description:	Higashide, E et al "Maridomycin, a New Macrolide Antibiotic" Program and Abstracts of the interscience science Conference on Antimicrobial Agents and Chemotherapy. 1971.
Institute where first reported:	Takeda Pharmaceuticals
Year first mentioned:	1971
Highest developmental phase:	Preclinical
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CCC(=O)OC1CC(=O)OC(C)CC2C(/C=C/C(C(C)CC(CC=O)C(C1OC)OC3C(C(C(C(C)O3)OC4CC(C)(C(C(C)O4)OC(=O)CC)O)N(C)C)O)O)O2
Isomeric SMILES:	CCC(=O)OC1CC(=O)OC(CC2C(O2)/C=C/C(C(CC(C(C1OC)OC3C(C(C(C(O3)C)OC4CC(C(C(O4)C)OC(=O)CC)(C)O)N(C)C)O)CC=O)C)O)C
InChI:	InChI=1S/C41H67NO16/c1-11-30(45)55-29-19-32(47)51-22(4)18-28-27(54-28)14-13-26(44)21(3)17-25(15-16-43)37(38(29)50-10)58-40-35(48)34(42(8)9)36(23(5)53-40)57-33-20-41(7,49)39(24(6)52-33)56-31(46)12-2/h13-14,16,21-29,33-40,44,48-49H,11-12,15,17-20H2,1-10H3/b14-13+
InChI Key:	FFXJTOKFQATYBI-BUHFOSPRSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6436045

External links:
Guide to Pharmacology:	maridomycin
Citations:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC444519/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC444520/