Compound ID | 1168

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KY-109

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Description: Second generation cephalosporin; prodrug with similar activity to cefamandole; Kakeya, N et al "New Orally Active Cephalosporin Esters, KY-101, KY-107 and KY-109" Program and Abstracts of the interscience science Conference on Antimicrobial Agents and Chemotherapy. 1983.
Institute where first reported: Kyoto Pharmaceuticals
Year first mentioned: 1983
Development status: Experimental
Chemical structure(s):
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Molecular weight: 698.19
Iso. SMILES: CC1=C(OC(=O)O1)COC(=O)C2=C(CS[C@H]3N2C(=O)[C@H]3NC(=O)[C@@H](C4=CC=CC=C4)OC(=O)[C@H](C)N)CSC5=NN=C(S5)C.Cl
InChI Key: HFVATKYQUGKLGL-PCQLZLFJSA-N
Can. SMILES: C[C@@H](C(=O)O[C@H](C1=CC=CC=C1)C(=O)N[C@@H]2C(=O)N3C(=C(CS[C@H]23)CSC4=NN=C(C)S4)C(=O)OCC5=C(C)OC(=O)O5)N.Cl
InChI: InChI=1S/C27H27N5O9S3.ClH/c1-12(28)24(35)41-20(15-7-5-4-6-8-15)21(33)29-18-22(34)32-19(25(36)38-9-17-13(2)39-27(37)40-17)16(10-42-23(18)32)11-43-26-31-30-14(3)44-26;/h4-8,12,18,20,23H,9-11,28H2,1-3H3,(H,29,33);1H/t12-,18+,20+,23+;/m0./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/179696
Citation: https://doi.org/10.7164/antibiotics.38.380

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