Compound ID | 117

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Nilofabicin

Synonym(s): CG-400549  |  CG549

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Fatty acid synthesis inhibitor. FabI inhibitor
Target Pathogen: Active against Staphylococcus aureus
Institute where first reported: CrystalGenomics, South Korea
Year first mentioned: 2006
Highest developmental phase: Phase 2 (NCT01593761)
Development status: Active
Chemical structure(s):
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Molecular weight: 340.44
Iso. SMILES: CC1=C(C=CC=C1N)CN2C=CC(=CC2=O)OCCC3=CC=CS3
InChI Key: YCLREGRRHGLOAK-UHFFFAOYSA-N
Can. SMILES: CC1=C(C=CC=C1CN2C=CC(=CC2=O)OCCC3=CC=CS3)N
InChI: InChI=1S/C19H20N2O2S/c1-14-15(4-2-6-18(14)20)13-21-9-7-16(12-19(21)22)23-10-8-17-5-3-11-24-17/h2-7,9,11-12H,8,10,13,20H2,1H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11844916
Guide to Pharmacology: nilofabicin
Citations:
  • https://www.ncbi.nlm.nih.gov/pubmed/17875997
  • http://www.ncbi.nlm.nih.gov/pubmed/24739388
  • http://www.crystalgenomics.com/en/m21_3.php?subPipeCate=2#main

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