Compound ID | 1180

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Ro 09-1428

Class: Beta-lactam (cephalosporin)

Spectrum of activity: Gram-negative
Details of activity: Active against Enterobacterales and Pseudomonas
Description: Arisawa, M "Ro 09-1428, a New Parental Cephalosporin: in Vitro Evaluation" Program and Abstracts of the interscience science Conference on Antimicro0bial Agents and Chemotherapy. 1989.
Institute where first reported: Roche Products Limitted
Year first mentioned: 1989
Highest development stage: Preclinical
Development status: Inactive
Chemical structure(s):
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Molecular weight: 813.85
Iso. SMILES: CC1=NC2=NC(=NN2C(=C1)SCC3=C(N4C(C(C4=O)NC(=O)/C(=N/OC(C)(C)C(=O)NNC(=O)C5=CC(=C(C=C5)O)O)/C6=CSC(=N6)N)SC3)C(=O)O)CO
InChI Key: CCOFMFVZORWSAE-KPRPFPDJSA-N
Can. SMILES: CC1=NC2=NC(=NN2C(=C1)SCC3=C(C(=O)O)N4C(=O)C(C4SC3)NC(=O)/C(=N/OC(C)(C)C(=O)NNC(=O)C5=CC=C(C(=C5)O)O)/C6=CSC(=N6)N)CO
InChI: InChI=1S/C31H31N11O10S3/c1-12-6-19(42-30(33-12)35-18(8-43)39-42)53-9-14-10-54-26-21(25(48)41(26)22(14)27(49)50)36-24(47)20(15-11-55-29(32)34-15)40-52-31(2,3)28(51)38-37-23(46)13-4-5-16(44)17(45)7-13/h4-7,11,21,26,43-45H,8-10H2,1-3H3,(H2,32,34)(H,36,47)(H,37,46)(H,38,51)(H,49,50)/b40-20+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9576896
Citations:
  • https://link.springer.com/article/10.1007/BF01975824
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC245074/

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