Compound ID | 1184

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Ficellomycin

Class: Aziridine

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: DNA synthesis inhibitor
Institute where first reported: The UpJohn Company
Year first mentioned: 1976
Highest developmental phase: Preclinical
Development status: Active
Reason Dropped: High MIC of fermentation broth means it hasn't attracted much attention, but engineered biosynthesis may make it a pheezable antibiotic.
Chemical structure(s):
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Molecular weight: 312.37
Iso. SMILES: CC(C)C(C(=O)NC(C1CC(C2N1C2)N=C(N)N)C(=O)O)N
InChI Key: DGIHWRUPUISVIZ-UHFFFAOYSA-N
Can. SMILES: CC(C)C(C(=O)NC(C1CC(C2CN12)N=C(N)N)C(=O)O)N
InChI: InChI=1S/C13H24N6O3/c1-5(2)9(14)11(20)18-10(12(21)22)7-3-6(17-13(15)16)8-4-19(7)8/h5-10H,3-4,14H2,1-2H3,(H,18,20)(H,21,22)(H4,15,16,17)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/151592
Guide to Pharmacology: ficellomycin
Citations:
  • https://www.jstage.jst.go.jp/article/antibiotics1968/29/10/29_10_1001/_article

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