Ficellomycin

Class: Aziridine

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	DNA synthesis inhibitor
Institute where first reported:	The UpJohn Company
Year first mentioned:	1976
Highest developmental phase:	Preclinical
Development status:	Active
Reason Dropped:	High MIC of fermentation broth means it hasn't attracted much attention, but engineered biosynthesis may make it a pheezable antibiotic.

Chemical structure(s):
Canonical SMILES:	CC(C)C(C(=O)NC(C1CC(C2CN12)N=C(N)N)C(=O)O)N
Isomeric SMILES:	CC(C)C(C(=O)NC(C1CC(C2N1C2)N=C(N)N)C(=O)O)N
InChI:	InChI=1S/C13H24N6O3/c1-5(2)9(14)11(20)18-10(12(21)22)7-3-6(17-13(15)16)8-4-19(7)8/h5-10H,3-4,14H2,1-2H3,(H,18,20)(H,21,22)(H4,15,16,17)
InChI Key:	DGIHWRUPUISVIZ-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/151592

External links:
Guide to Pharmacology:	ficellomycin
Citation:	https://www.jstage.jst.go.jp/article/antibiotics1968/29/10/29_10_1001/_article