Compound ID | 1186

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Faropenem medoxomil

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against pathogens causing community acquired pneumonia
Institute where first reported: Asubio Pharma
Year first mentioned: 1995
Highest development stage: Phase 3 (NCT00255983)
Development status: Inactive
Reason dropped: Financial reasons
Chemical structure(s):
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Molecular weight: 397.4
Iso. SMILES: CC1=C(OC(=O)O1)COC(=O)C2=C(S[C@H]3N2C(=O)[C@@H]3[C@@H](C)O)[C@H]4CCCO4
InChI Key: JQBKWZPHJOEQAO-DVPVEWDBSA-N
Can. SMILES: C[C@H]([C@H]1C(=O)N2C(=C([C@H]3CCCO3)S[C@H]12)C(=O)OCC4=C(C)OC(=O)O4)O
InChI: InChI=1S/C17H19NO8S/c1-7(19)11-14(20)18-12(13(27-15(11)18)9-4-3-5-23-9)16(21)24-6-10-8(2)25-17(22)26-10/h7,9,11,15,19H,3-6H2,1-2H3/t7-,9-,11+,15-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6918218
Guide to Pharmacology: faropenem
Citations:
  • https://doi.org/10.1586/14787210.4.6.923
  • https://journals.asm.org/doi/10.1128/aac.01566-08

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