Compound ID | 1188

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MGB-BP-3

Class: DNA synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. Binds to minor groove of DNA
Target Pathogen: Active against resistant streptococci, staphylococci and enterococci
Description: Ravic. M., Firmin. D., Suckling. C., Hunter. I., Lundberg. C., Jensen. K. "in vivo Antimicrobial Activity of MGB-BP-3, a New Class of Antibacterial Agent, in Murine Infection Models " Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 2015.
Institute where first reported: MGB Biopharma
Year first mentioned: 2015
Highest development stage: Phase 2 (NCT03824795)
Development status: Active
Chemical structure(s):
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Molecular weight: 631.72
Iso. SMILES: CN1C=C(C=C1C(=O)NC2=CN(C(=C2)C(=O)NCCN3CCOCC3)C)NC(=O)C4=CC=C(C=C4)/C=C/C5=CC6=CC=CC=C6N=C5
InChI Key: OEKXCVYZBVOWBR-BQYQJAHWSA-N
Can. SMILES: CN1C=C(C=C1C(=O)NCCN2CCOCC2)NC(=O)C3=CC(=CN3C)NC(=O)C4=CC=C(/C=C/C5=CC6=C(C=CC=C6)N=C5)C=C4
InChI: InChI=1S/C36H37N7O4/c1-41-24-30(20-32(41)35(45)37-13-14-43-15-17-47-18-16-43)40-36(46)33-21-29(23-42(33)2)39-34(44)27-11-9-25(10-12-27)7-8-26-19-28-5-3-4-6-31(28)38-22-26/h3-12,19-24H,13-18H2,1-2H3,(H,37,45)(H,39,44)(H,40,46)/b8-7+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/23730143
Guide to Pharmacology: MGB-BP-3
Citation: https://doi.org/10.1021/acsinfecdis.2c00445

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