Compound ID | 1192

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ACT 387042

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-positive
Details of activity: Topoisomerase inhibitor with activity against steptococci and staphylococci
Description: Lepak. A., Seiler. P., Surivet. J., Ritz. D., Kohl. C and Ander. A. "Pharmacokinetic/pharmacodynamic Evaluation of a Novel Topo-isomerase Inhibitor, ACT-387042, in a Murine Thigh and Lung Infection Model Against Staphylococcus aureus (sa) and Streptococcus pneumoniae (spn) " Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 2015.
Institute where first reported: Actelion Pharmaceuticals
Year first mentioned: 2015
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 487.55
Iso. SMILES: COC1=NC2=C(C(=CN=C2C=C1)F)C[C@@H]([C@@H]3CC[C@H](CO3)NCC4=CC5=C(N=N4)OCCS5)O
InChI Key: JYSPYEGADQXZPH-VMDGZTHMSA-N
Can. SMILES: COC1=CC=C2C(=N1)C(=C(C=N2)F)C[C@@H]([C@@H]3CC[C@H](CO3)NCC4=NN=C5C(=C4)SCCO5)O
InChI: InChI=1S/C23H26FN5O4S/c1-31-21-5-3-17-22(27-21)15(16(24)11-26-17)9-18(30)19-4-2-13(12-33-19)25-10-14-8-20-23(29-28-14)32-6-7-34-20/h3,5,8,11,13,18-19,25,30H,2,4,6-7,9-10,12H2,1H3/t13-,18+,19+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/46235398
Citation: http://www.abstractsonline.com/plan/ViewAbstract.aspx?mID=3798&sKey=066fe91c-1dff-48d2-a97e-9d682ce3a71c&cKey=7487bfe0-b55a-41c5-a4c7-861bcd17e3f8&mKey=7a574a80-eab1-4b50-b343-4695df14907e

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