Compound ID | 1200

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CA-900

Class: Polymyxin

Spectrum of activity: Gram-negative
Details of activity: Disrupts the outer membrane by direct interaction with the lipid A component of the LPS and and disrupts the physical integrity of the phospholipid bilayer of the inner membrane, and possibly additional modes of action. Polymyxin B derivatives with activity against Acinetobacter, Pseudomonas and Escherichia
Description: Polymixin B Derivative
Institute where first reported: Univ. of Milano-Bicocca
Year first mentioned: 2015
Highest developmental phase: Preclinical
Development status: Active
External links:
Citation: http://www.abstractsonline.com/plan/ViewAbstract.aspx?mID=3798&sKey=e9282513-65dd-4571-8dd4-cb67481cbcdb&cKey=6352cd78-59d5-4a66-9854-01c8c2a345a0&mKey=7a574a80-eab1-4b50-b343-4695df14907e

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