Compound ID | 1205

Update compound information

AM-1977

Class: Quinolone

Spectrum of activity: Gram-positive
Details of activity: Activity against gram-positive and negative organisms, but specifically Gram-Positive cocci
Description: Yamagishi. Y., Matsukawa. Y., Suematsu. H., Koizumi. Y., Hirai. J., Nishiyama. N., Mikama. H. "AM-1977, A New Generation Broad Spectrum Fluoroquinolone: In Vitro Antibacterial Activity Against Anaerobes Isolated in Japan " Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 2015.
Institute where first reported: RedX Anti-Infectives Ltd
Year first mentioned: 2015
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 439.43
Iso. SMILES: COC1=C2C(=CC(=C1N3C[C@@H]([C@@H](C3)F)CNC4CC4)F)C(=O)C(=CN2CCF)C(=O)O
InChI Key: ZFIOCUITTUUVPV-MEDUHNTESA-N
Can. SMILES: COC1=C(C(=CC2=C1N(CCF)C=C(C2=O)C(=O)O)F)N3C[C@H](CNC4CC4)[C@@H](C3)F
InChI: InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71528768
Citation: http://www.abstractsonline.com/plan/ViewAbstract.aspx?mID=3798&sKey=37b09dcf-f2b5-4e67-aa0d-3f43f3fc4972&cKey=a363cee5-ee4a-409f-814b-185b3597b2e5&mKey=7a574a80-eab1-4b50-b343-4695df14907e

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