Compound ID | 1206

Update compound information

REDX04139

Class: Bacterial topoisomerase inhibitor

Spectrum of activity: Gram-positive
Details of activity: Tricyclic inhibitor, chemically distinct from the quinolones. Good activity against ciprofloxacin resistant S. aureus
Description: Huxley. A., Savage. V., Kirk. R., Uosis-Martin. M., Charrier. C., Lyth. D., Salisbury. A., Moyo. E., Stovold. R., Metzger. R., Mohmed. S., Craighead. M., Chaffer_Malam. N., Ratcliffe. A., Cheung. J., Stokes. N. "Novel Tricyclic Topoisomerase Inhibitors (NTTIs) with Potent Activity against Drug-Resistant Bacteria " Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 2015.
Year first mentioned: 2015
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 367.35
Iso. SMILES: FC1=C(C2=CC=C3C(N(C4CC4)C(C5=C3OC=N5)=O)=C2C)C=C(F)C(N)=C1
InChI Key: KBUYQPMNHBXXOV-UHFFFAOYSA-N
Can. SMILES: CC1=C(C=CC2=C1N(C3CC3)C(=O)C4=C2OC=N4)C5=C(C=C(C(=C5)F)N)F
InChI: InChI=1S/C20H15F2N3O2/c1-9-11(13-6-15(22)16(23)7-14(13)21)4-5-12-18(9)25(10-2-3-10)20(26)17-19(12)27-8-24-17/h4-8,10H,2-3,23H2,1H3
External links:
Citation: https://academic.oup.com/jac/article/71/7/1905/1750748
Patents:
  • US patents 9,315,495, 9,592,221
  • US provisional patents 62/630117, 62/630122
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