Avarofloxacin

Synonym(s): JNJ-Q2

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive
Details of activity:	Active against methicillin-resistant Staphylococcus aureus
Description:	Broad Spectrum In Vitro Activity of JNJ-Q2, a New Fluoroquinolone. F1-2033. 48th Annu. Intersci. Conf. Antimicrob. Agents Chemother. (ICAAC)-Infect. Dis. Soc. Am. (IDSA) 46th Annu. Meet. American Society for Microbiology and Infectious Diseases Society of America, Washington, DC. By: Foleno, B
Institute where first reported:	Johnson & Johnson, Melinta Therapeutics Inc.
Year first mentioned:	2008
Highest developmental phase:	Phase 2 (NCT01128530)
Development status:	Active

Chemical structure(s):
Canonical SMILES:	COC1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)F)N4CCC/C(=C(/CN)\F)/C4
Isomeric SMILES:	COC1=C2C(=CC(=C1N3CCC/C(=C(/CN)\F)/C3)F)C(=O)C(=CN2C4CC4)C(=O)O
InChI:	InChI=1S/C21H23F2N3O4/c1-30-20-17-13(19(27)14(21(28)29)10-26(17)12-4-5-12)7-15(22)18(20)25-6-2-3-11(9-25)16(23)8-24/h7,10,12H,2-6,8-9,24H2,1H3,(H,28,29)/b16-11+
InChI Key:	VMKVDAAFMQKZJS-LFIBNONCSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/11546234

External links:
Guide to Pharmacology:	acorafloxacin