Compound ID | 1219

Update compound information

ETX2514SUL (Sulbactam + ETX2514)

Class: Beta-lactam + beta-lactamase inhibitor

Agent Type: Semisynthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Beta-lactamase inhibitor
Target Pathogen: Active against pathogens causing complicated urinary tract infections including acute pyelonephritis, and hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia
Combined with other compounds: yes
Institute where first reported: Entasis Therapeutics Inc.
Highest development stage: Approved by FDA
Development status: Approved
Chemical structure(s):
Sulbactam
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Molecular weight: 233.24
Iso. SMILES: CC1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)O)C
InChI Key: FKENQMMABCRJMK-RITPCOANSA-N
Can. SMILES: CC1(C)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
InChI: InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
ETX2514
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Molecular weight: 279.27
Iso. SMILES: CC1=C[C@H](CN([C@@H]1C(=O)N)C=O)NOS(=O)(=O)O
InChI Key: DDVLLOCREWHCBP-RQJHMYQMSA-N
Can. SMILES: CC1=C[C@H](CN(C=O)[C@@H]1C(=O)N)NOS(=O)(=O)O
InChI: InChI=1S/C8H13N3O6S/c1-5-2-6(10-17-18(14,15)16)3-11(4-12)7(5)8(9)13/h2,4,6-7,10H,3H2,1H3,(H2,9,13)(H,14,15,16)/t6-,7+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/130313
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/89851851
Citations:
  • https://clinicaltrials.gov/ct2/show/NCT03445195
  • https://doi.org/10.1128/aac.01089-18
  • http://www.entasistx.com/pipeline

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