Imipenem with cilastatin

Synonym(s): Primaxin

Class: Beta-lactam (thienamycin)

Spectrum of activity:	Gram-positive  &  Gram-negative
Combined with other compounds:
Description:	Cilastatin inhibits the human renal dehydropeptidase preventing systemic degradation of imipenem
Institute where first reported:	Merck
Highest developmental phase:	Approved by FDA in 1985
Development status:	Approved
Reason Dropped:	Other formulations were discontinued

Chemical structure(s):
Canonical SMILES:	C[C@H]([C@@H]1[C@H]2CC(=C(C(=O)O)N2C1=O)SCCN=CN)O
Isomeric SMILES:	C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O
InChI:	InChI=1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1
InChI Key:	ZSKVGTPCRGIANV-ZXFLCMHBSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/104838

External links:
Guide to Pharmacology:	cilastatin
Patent:	US7507814B2