Compound ID | 1220

Update compound information

Imipenem + Cilastatin

Synonym(s): Primaxin  |  Imipenem with Cilastatin  |  Imipenem and Cilastatin  |  Imipenem/Cilastatin

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Cell wall synthesis inhibitor
Combined with other compounds:
Description: A thienamycin-type; cilastatin inhibits the human renal dehydropeptidase preventing systemic degradation of imipenem
Institute where first reported: Merck
Highest development stage: Approved by FDA in 1985
Development status: Approved
Reason dropped: Other formulations were discontinued
Chemical structure(s):
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Molecular weight: 299.35
Iso. SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O
InChI Key: ZSKVGTPCRGIANV-ZXFLCMHBSA-N
Can. SMILES: C[C@H]([C@@H]1[C@H]2CC(=C(C(=O)O)N2C1=O)SCCN=CN)O
InChI: InChI=1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/104838
Guide to Pharmacology: cilastatin
Patent: US7507814B2

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