Compound ID | 1225

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BOS 228

Synonym(s): ancremonam  |  LYS228  |  BOS-228  |  BOS228  |  BOS-228  |  BOS 228

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Penicillin binding protein inhibitor (PBP inhibitor)
Target Pathogen: Active against Enterobacteriaceae
Description: A monobactam; indicated for urinary tract infections and complicated intraabdominal infections
Institute where first reported: Boston Pharmaceuticals (Licensed from Novartis AG)
Highest development stage: Phase 2
Development status: Active
Chemical structure(s):
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Molecular weight: 518.48
Iso. SMILES: C1CC1(C(=O)O)O/N=C(/C2=CSC(=N2)N)\C(=O)N[C@H]3[C@H](N(C3=O)S(=O)(=O)O)CN4CCOC4=O
InChI Key: FWTGYTRQUBRVDW-NRABZWKMSA-N
Can. SMILES: C1CC1(C(=O)O)O/N=C(/C2=CSC(=N2)N)\C(=O)N[C@H]3[C@@H](CN4CCOC4=O)N(C3=O)S(=O)(=O)O
InChI: InChI=1S/C16H18N6O10S2/c17-14-18-7(6-33-14)9(20-32-16(1-2-16)13(25)26)11(23)19-10-8(5-21-3-4-31-15(21)27)22(12(10)24)34(28,29)30/h6,8,10H,1-5H2,(H2,17,18)(H,19,23)(H,25,26)(H,28,29,30)/b20-9-/t8-,10+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/118379834
Guide to Pharmacology: ancremonam
Citations:
  • https://aac.asm.org/content/62/10/e01200-18
  • https://aac.asm.org/content/63/7/e02592-18
  • https://www.novartis.com/news/media-releases/novartis-licenses-three-novel-anti-infective-programs-boston-pharmaceuticals

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