Compound ID | 1227

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Zifanocycline

Synonym(s): KBP-7072

Class: Tetracycline

Spectrum of activity: Gram-positive & Gram-negative
Details of activity: Community-acquired bacterial pneumonia
Description: https://aac.asm.org/content/64/5/e02375-19
Institute where first reported: KBP BioSciences Pharmaceutical Technical Co. Ltd.
Highest development stage: Phase 1
Development status: Active
Chemical structure(s):
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Molecular weight: 552.62
Iso. SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=C(C(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)CN5CC6CC6C5)N(C)C
InChI Key: LBKXOQRVWDAQSX-OMBSCLNISA-N
Can. SMILES: CN(C)C1=C2C[C@H]3C[C@H]4[C@@H](C(=O)C(=C([C@]4(C(=O)C3=C(C2=C(C(=C1)CN5CC6CC6C5)O)O)O)O)C(=O)N)N(C)C
InChI: InChI=1S/C29H36N4O7/c1-31(2)18-8-15(11-33-9-13-5-14(13)10-33)23(34)20-16(18)6-12-7-17-22(32(3)4)25(36)21(28(30)39)27(38)29(17,40)26(37)19(12)24(20)35/h8,12-14,17,22,34-35,38,40H,5-7,9-11H2,1-4H3,(H2,30,39)/t12-,13?,14?,17-,22-,29-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/71243332
Guide to Pharmacology: zifanocycline
Citations:
  • https://aac.asm.org/content/64/6/e00488-20
  • https://www.biorxiv.org/content/10.1101/508218v1
  • https://www.ncbi.nlm.nih.gov/pubmed/30559140
  • https://kbpbiosciences.com/kbp-7072-obtained-qidp-and-fast-track-designations/

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