Ibezapolstat

Synonym(s): ACX-362E

Class: DNA synthesis inhibitor

Spectrum of activity:	Gram-positive
Details of activity:	C. difficile infections
Institute where first reported:	Acurx Pharmaceuticals LLC
Highest developmental phase:	Phase 2
Development status:	Active

Chemical structure(s):
Canonical SMILES:	C1=C(C=C(C(=C1)Cl)Cl)CNC2=NC3=C(C(=O)N2)N(CCN4CCOCC4)C=N3
Isomeric SMILES:	C1COCCN1CCN2C=NC3=C2C(=O)NC(=N3)NCC4=CC(=C(C=C4)Cl)Cl
InChI:	InChI=1S/C18H20Cl2N6O2/c19-13-2-1-12(9-14(13)20)10-21-18-23-16-15(17(27)24-18)26(11-22-16)4-3-25-5-7-28-8-6-25/h1-2,9,11H,3-8,10H2,(H2,21,23,24,27)
InChI Key:	DEGSGBKTODESHH-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/136022209

External links:
Guide to Pharmacology:	ibezapolstat
Main Source:	https://www.acurxpharma.com/news-media/press-releases/detail/9/acurx-successfully-completes-ph1-clinical-trial-for
Citations:	https://d1io3yog0oux5.cloudfront.net/_f012ec721fe24818a37a194d128bce74/acurxpharma/db/412/2841/pdf/Torti_CEI_2011.pdf https://d1io3yog0oux5.cloudfront.net/_f012ec721fe24818a37a194d128bce74/acurxpharma/db/412/2842/pdf/Dvoskin_AAC_2011.pdf https://d1io3yog0oux5.cloudfront.net/_f012ec721fe24818a37a194d128bce74/acurxpharma/db/412/2843/pdf/Van_Eijk_Poster_ECCMID_2012.pdf