Compound ID | 1231

Update compound information

Ibezapolstat

Synonym(s): ACX-362E

Class: DNA synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. DNA Polymerase C inhibitor; DNA PolC inhibitor
Target Pathogen: Active against Clostridium difficile infection
Institute where first reported: Acurx Pharmaceuticals LLC
Highest development stage: Phase 2
Development status: Active
Chemical structure(s):
Click here for structure editor
Molecular weight: 423.3
Iso. SMILES: C1COCCN1CCN2C=NC3=C2C(=O)NC(=N3)NCC4=CC(=C(C=C4)Cl)Cl
InChI Key: DEGSGBKTODESHH-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)Cl)Cl)CNC2=NC3=C(C(=O)N2)N(CCN4CCOCC4)C=N3
InChI: InChI=1S/C18H20Cl2N6O2/c19-13-2-1-12(9-14(13)20)10-21-18-23-16-15(17(27)24-18)26(11-22-16)4-3-25-5-7-28-8-6-25/h1-2,9,11H,3-8,10H2,(H2,21,23,24,27)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/136022209
Guide to Pharmacology: ibezapolstat
Citations:
  • https://d1io3yog0oux5.cloudfront.net/_f012ec721fe24818a37a194d128bce74/acurxpharma/db/412/2841/pdf/Torti_CEI_2011.pdf
  • https://d1io3yog0oux5.cloudfront.net/_f012ec721fe24818a37a194d128bce74/acurxpharma/db/412/2842/pdf/Dvoskin_AAC_2011.pdf
  • https://d1io3yog0oux5.cloudfront.net/_f012ec721fe24818a37a194d128bce74/acurxpharma/db/412/2843/pdf/Van_Eijk_Poster_ECCMID_2012.pdf
  • https://www.acurxpharma.com/news-media/press-releases/detail/9/acurx-successfully-completes-ph1-clinical-trial-for

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.