Compound ID | 1235

Update compound information

GYROX

Synonym(s): BWC0977  |  BWC 0977  |  BWC-0977

Class: Bacterial topoisomerase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Bacterial topoisomerase inhibitor
Institute where first reported: Bugworks Research
Highest development stage: Phase 1
Development status: Active
Chemical structure(s):
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Molecular weight: 468.44
Iso. SMILES: CN1C(=O)C=CC2=C1C(=C(C=C2)F)CCNC[C@@H]3CN(C4=NC5=C(N=C4)OCC(=O)N5)C(=O)O3
InChI Key: MKICNOUBIXXGPQ-CYBMUJFWSA-N
Can. SMILES: CN1C(=O)C=CC2=C1C(=C(C=C2)F)CCNC[C@@H]3CN(C4=NC5=C(N=C4)OCC(=O)N5)C(=O)O3
InChI: InChI=1S/C22H21FN6O5/c1-28-18(31)5-3-12-2-4-15(23)14(19(12)28)6-7-24-8-13-10-29(22(32)34-13)16-9-25-21-20(26-16)27-17(30)11-33-21/h2-5,9,13,24H,6-8,10-11H2,1H3,(H,26,27,30)/t13-/m1/s1
External links:
Guide to Pharmacology: BWC0977
Citations:
  • https://doi.org/10.1038/s41467-025-57400-w
  • https://carb-x.org/gallery/bugworks/

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