GYROX

Synonym(s): BWC0977

Class: Bacterial topoisomerase inhibitor

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, interferes with DNA replication
Institute where first reported:	Bugworks Research
Highest developmental phase:	Phase 1
Development status:	Active

Chemical structure(s):
Canonical SMILES:	CN1C(=O)C=CC2=C1C(=C(C=C2)F)CCNC[C@@H]3CN(C4=NC5=C(N=C4)OCC(=O)N5)C(=O)O3
Isomeric SMILES:	CN1C(=O)C=CC2=C1C(=C(C=C2)F)CCNC[C@@H]3CN(C4=NC5=C(N=C4)OCC(=O)N5)C(=O)O3
InChI:	InChI=1S/C22H21FN6O5/c1-28-18(31)5-3-12-2-4-15(23)14(19(12)28)6-7-24-8-13-10-29(22(32)34-13)16-9-25-21-20(26-16)27-17(30)11-33-21/h2-5,9,13,24H,6-8,10-11H2,1H3,(H,26,27,30)/t13-/m1/s1
InChI Key:	MKICNOUBIXXGPQ-CYBMUJFWSA-N

External links:
Guide to Pharmacology:	BWC0977
Main Source:	https://carb-x.org/gallery/bugworks/