Compound ID | 1245

Update compound information

RC-01

Synonym(s): T-1228  |  T1228  |  T 1228  |  RC01  |  RC 01

Class: Lipopolysaccharide synthesis inhibitor

Agent Type: Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Lipopolysaccharide synthesis inhibitor. LpxC inhibitor
Target Pathogen: Active against Enterobacteriaceae including Pseudomonas aeruginosa
Institute where first reported: Recida Therapeutics; Fujifilm Toyama Chemical Co. Ltd. (Toyoma, Japan)
Highest development stage: Phase 1
Development status: Inactive
Reason dropped: Toxicity; prematurely terminated
External links:
Citations:
  • https://carb-x.org/carb-x-news/carb-x-funds-recida-therapeutics-to-develop-a-new-class-of-antibiotics-to-treat-deadly-infections-caused-by-gram-negative-superbugs/
  • https://catalyspacific.com/2019/04/01/recida-therapeutics-announces-the-initiation-of-a-phase-i-clinical-trial-of-rc-01-a-novel-lpxc-inhibitor/

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