Compound ID | 125

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Zabofloxacin

Synonym(s): DW-224a

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Community-acquired bacterial pneumonia
Description: Analogue of gemifloxacin
Institute where first reported: Dong Wha Pharmaceutical, South Korea
Year first mentioned: 2003
Highest developmental phase: Phase 3 (NCT01658020)
Development status: Active
Chemical structure(s):
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Molecular weight: 401.39
Iso. SMILES: CO/N=C\1/CN(CC12CNC2)C3=C(C=C4C(=O)C(=CN(C4=N3)C5CC5)C(=O)O)F
InChI Key: ZNPOCLHDJCAZAH-UCQKPKSFSA-N
Can. SMILES: CO/N=C\1/CN(CC21CNC2)C3=NC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(=O)O
InChI: InChI=1S/C19H20FN5O4/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28)/b23-14-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9952872
Guide to Pharmacology: zabofloxacin
Citations:
  • https://www.jstage.jst.go.jp/article/bpb/26/6/26_6_832/_pdf
  • http://www.sciencedirect.com/science/article/pii/S0732889308002678
  • https://www.dong-wha.co.kr/english/customer/dnews/content.asp?t_idx=856

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