Compound ID | 1257

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Kaempferol

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule;
Spectrum of activity: Gram-negative
Mechanism of action: Unknown
Target Pathogen: Active against Helicobacter pylori
Description: A natural flavonoid
Institute where first reported: Aragon Institute for Health Research (IIS Aragón), Zaragoza, Spain, Department of Biochemistry and Molecular & Cellular Biology, University of Zaragoza, Zaragoza, Spain, Institute for Biocomputation and Physics of Complex Systems & ARAID Foundation, Zaragoza, Spain, Cancer Science Institute, National University of Singapore, Singapore, Singapore, Department of Microbiology, University of Zaragoza & CIBERes, Zaragoza, Spain, Digestive Diseases Service, University Clinic Hospital Lozano Blesa & CIBERehd, Zaragoza, Spain
Development status: Experimental
Chemical structure(s):
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Molecular weight: 286.24
Iso. SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChI Key: IYRMWMYZSQPJKC-UHFFFAOYSA-N
Can. SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O)O)O2)O)O
InChI: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5280863
Guide to Pharmacology: kaempferol
Citations:
  • https://journals.asm.org/doi/10.1128/spectrum.02265-22
  • https://www.escmid.org/escmid_publications/escmid_elibrary/?q=Small-molecule+inhibitors+of+the+essential+response+regulator+HsrA+exhibit+strong+bactericidal+activity+against+Helicobacter+pylori&id=2173&L=0&x=0&y=0&tx_solr%5Bfilter%5D%5B0%5D=main_filter_eccmid%253Atrue

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