Ivermectin/Colistin

Spectrum of activity:	Gram-negative
Details of activity:	Antibacterial effect of colistin against Col-S and Col-R A. baumannii, P. aeruginosa and K. pneumoniae.
Combined with other compounds:	Yes
Institute where first reported:	Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen del Rocío, Seville, Spain. Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain., Sevilla, Spain, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain. Department of Medicine, University of Seville, Seville, Spain., Sevilla, Spain
Year first mentioned:	2019
Highest developmental phase:	Preclinical
Development status:	Active

Chemical structure(s):
Ivermectin
Canonical SMILES:	CCC(C)C1C(C)CC[C@]2(C[C@@H]3CC(C/C=C(\C)/C(C(C)/C=C/C=C/4\COC5[C@@H](C(=C[C@@H](C(=O)O3)C45O)C)O)O[C@H]6C[C@@H](C([C@H](C)O6)O[C@H]7C[C@@H](C([C@H](C)O7)O)OC)OC)O2)O1
Isomeric SMILES:	CCC(C)C1C(CC[C@@]2(O1)C[C@@H]3CC(O2)C/C=C(/C(C(/C=C/C=C/4\COC5C4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H](C([C@@H](O6)C)O[C@H]7C[C@@H](C([C@@H](O7)C)O)OC)OC)\C)C
InChI:	InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25?,26?,28?,30-,31-,33?,34-,35-,36-,37-,38-,39-,40+,41?,42?,43?,44?,45?,47+,48?/m0/s1
InChI Key:	AZSNMRSAGSSBNP-ZLRQRZFZSA-N
Colistin
Canonical SMILES:	CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O
Isomeric SMILES:	CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C(NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
InChI:	InChI=1S/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36-,37+,38-,39-,41?,42+/m1/s1
InChI Key:	YKQOSKADJPQZHB-RGYSVOEGSA-N

External links:
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6427057
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/44144393
Guide to Pharmacology:	ivermectin
Main Source:	https://www.eccmidlive.org/#!resources/in-vitro-activity-of-ivermectin-in-combination-with-colistin-against-gram-negative-bacilli-5b1695c5-cf06-4761-baee-d2ab3646d5c4