Compound ID | 127

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Oxantel

Class: Antibiofilm agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiofilm;
Spectrum of activity: Gram-negative
Mechanism of action: Fumarate reductase inhibitor
Target Pathogen: Active against proteolytic species Porphyromonas gingivalis and Tannerella forsythia; indicated for chronic periodontitis
Institute where first reported: Oral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Victoria, Australia
Year first mentioned: 1975
Development status: Experimental
Chemical structure(s):
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Molecular weight: 216.28
Iso. SMILES: CN1CCCN=C1/C=C/C2=CC(=CC=C2)O
InChI Key: VRYKTHBAWRESFI-VOTSOKGWSA-N
Can. SMILES: CN1CCCN=C1/C=C/C2=CC=CC(=C2)O
InChI: InChI=1S/C13H16N2O/c1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h2,4-7,10,16H,3,8-9H2,1H3/b7-6+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5281087
Guide to Pharmacology: oxantel
Citations:
  • http://aac.asm.org/content/58/1/378.full
  • https://www.ncbi.nlm.nih.gov/pubmed/12913453

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