Compound ID | 1278

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Zidebactam

Synonym(s): WCK 5107  |  WCK-5107  |  WCK5107

Class: Beta-lactam

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. PBP inhibitor; also known to be a beta-lactam enhancer (BLE)
Target Pathogen: Active against Enterobacteriaceae
Institute where first reported: Wockhardt
Year first mentioned: 2017
Highest development stage: Phase 1
Development status: Active
Chemical structure(s):
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Molecular weight: 391.4
Iso. SMILES: C1C[C@H](CNC1)C(=O)NNC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OS(=O)(=O)O
InChI Key: YCZPXRQPDCXTIO-BBBLOLIVSA-N
Can. SMILES: C1C[C@H](CNC1)C(=O)NNC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OS(=O)(=O)O
InChI: InChI=1S/C13H21N5O7S/c19-11(8-2-1-5-14-6-8)15-16-12(20)10-4-3-9-7-17(10)13(21)18(9)25-26(22,23)24/h8-10,14H,1-7H2,(H,15,19)(H,16,20)(H,22,23,24)/t8-,9-,10+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/77846445
Guide to Pharmacology: zidebactam
Citation: https://aac.asm.org/content/61/6/e02529-16

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