Compound ID | 1279

Update compound information

NXL-105

Synonym(s): NXL105  |  NXL 105

Class: Beta-lactam + beta-lactamase inhibitor

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-negative
Mechanism of action: Cell wall synthesis inhibitor. Also a beta-lactamase inhibitor (Class A beta-lactamase inhibitor)
Target Pathogen: Only active against Escherichia coli and Pseudomonas aeruginosa
Institute where first reported: Entasis Therapeutics
Year first mentioned: 2019
Development status: Experimental
Reason dropped: Not efficacious against Pseudomonas aeruginosa in vivo
Chemical structure(s):
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Molecular weight: 303.3
Iso. SMILES: CN1C2=C(C=N1)[C@@H]3CN([C@@H]2CN)C(=O)N3OS(=O)(=O)O
InChI Key: RQBKZSHXCSVMSL-RQJHMYQMSA-N
Can. SMILES: CN1C2=C(C=N1)[C@@H]3CN([C@@H]2CN)C(=O)N3OS(=O)(=O)O
InChI: InChI=1S/C9H13N5O5S/c1-12-8-5(3-11-12)7-4-13(6(8)2-10)9(15)14(7)19-20(16,17)18/h3,6-7H,2,4,10H2,1H3,(H,16,17,18)/t6-,7+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/146626473

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