Compound ID | 1286

Update compound information

Nisin

Class: Antimicrobial peptide (cationic)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
Institute where first reported: Saint Joseph University of Beirut, Microbiology Laboratory, School of Pharmacy, Beirut, Lebanon, Zayed University, College of Natural and Health Sciences, Dubai, United Arab Emirates, Institut Pasteur/Faculté de médecine Cochin, Unité de Mucoviscidose et Bronchopathies Chroniques
Year first mentioned: 2019
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
Click here for structure editor
Molecular weight: 3354.08
Iso. SMILES: CCC(C)C1C(=O)NC(C(=O)NCC(=O)NC(CSC(C(C(=O)NCC(=O)NC(C(=O)N1)C)NC(=O)C(CCCCN)NC(=O)C2CSC(C(C(=O)N3CCCC3C(=O)NCC(=O)N2)NC(=O)C4CSCC(C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)N4)C(C)CC)C(C)CC)NC(=O)/C(=C/C)/NC(=O)C(C(C)CC)N)C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC5C(SCC6C(=O)NC(C(=O)NC(CSC(C(C(=O)N6)NC(=O)C(NC5=O)C)C)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CC7=CN=CN7)C(=O)NC(C(C)C)C(=O)NC(=C)C(=O)NC(CCCCN)C(=O)O)CC8=CN=CN8)C)CCSC
InChI Key: VOSQDGQTENUVIE-INNOLEBESA-N
Can. SMILES: CCC(C)C(C(=O)N/C(=C\C)/C(=O)NC1CSCC(C(=O)NC2C(C)SCC(C(=O)NC(CCCCN)C(=O)NC3C(C)SCC(C(=O)NC(CC(=O)N)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC4C(C)SCC5C(=O)NC(CC6=CN=CN6)C(=O)NC(CSC(C)C(C(=O)N5)NC(=O)C(C)NC4=O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CC7=CN=CN7)C(=O)NC(C(C)C)C(=O)NC(=C)C(=O)NC(CCCCN)C(=O)O)NC(=O)CNC(=O)C(CCSC)NC(=O)C(C(C)CC)NC(=O)C(C)NC(=O)CNC3=O)NC(=O)CNC(=O)C8CCCN8C2=O)NC(=O)C(C(C)CC)NC(=O)C(=C)NC(=O)C(C(C)CC)NC1=O)N
InChI: InChI=1S/C143H230N42O37S7/c1-24-67(9)103(148)133(211)162-82(29-6)118(196)172-92-58-225-59-93(174-139(217)107(70(12)27-4)178-115(193)74(16)158-136(214)105(68(10)25-2)180-130(92)208)131(209)184-112-79(21)229-61-94(160-102(190)56-152-132(210)98-40-36-46-185(98)142(112)220)126(204)164-84(38-31-34-44-145)120(198)182-109-76(18)226-60-95(161-101(189)55-151-117(195)85(41-47-223-22)166-137(215)106(69(11)26-3)177-114(192)72(14)156-100(188)54-153-134(109)212)127(205)169-90(51-99(147)187)123(201)165-86(42-48-224-23)119(197)163-83(37-30-33-43-144)121(199)183-110-77(19)228-63-97-128(206)168-88(49-80-52-149-64-154-80)122(200)173-96(62-227-78(20)111(141(219)175-97)181-116(194)75(17)159-140(110)218)129(207)171-91(57-186)125(203)179-108(71(13)28-5)138(216)170-89(50-81-53-150-65-155-81)124(202)176-104(66(7)8)135(213)157-73(15)113(191)167-87(143(221)222)39-32-35-45-146/h29,52-53,64-72,75-79,83-98,103-112,186H,15-16,24-28,30-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,210)(H,153,212)(H,156,188)(H,157,213)(H,158,214)(H,159,218)(H,160,190)(H,161,189)(H,162,211)(H,163,197)(H,164,204)(H,165,201)(H,166,215)(H,167,191)(H,168,206)(H,169,205)(H,170,216)(H,171,207)(H,172,196)(H,173,200)(H,174,217)(H,175,219)(H,176,202)(H,177,192)(H,178,193)(H,179,203)(H,180,208)(H,181,194)(H,182,198)(H,183,199)(H,184,209)(H,221,222)/b82-29-
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16133879
Citation: https://www.escmid.org/escmid_publications/escmid_elibrary/?q=Cationic+antimicrobial+peptides%3A+alternatives+and%2For+adjuvants+to+antibiotics+active+against+multidrug-resistant+Staphylococcus+aureus+and+Pseudomonas+aeruginosa&id=2173&L=0&x=0&y=0

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.